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Conolidine is a natural alkaloid derived from the bark of your tropical shrub Tabernaemontana divaricata, also called crepe jasmine. This shrub was typically used in Chinese, Ayurvedic, and Thai medicine, and is well-liked for its powerful pain-relieving properties.Szpakowska et al. also analyzed conolidone and its action to the ACKR3 receptor, whi